Susceptibilidad genética del cáncer colorrectal en el adulto joven: identificación de regiones cromosómicas de interés y búsqueda de genes de alta y baja penetrancia.

Preliminary studies in our group, in samples proceeding from colon cancer both in the young adult and in patients of advanced age (over 70 years old) by aCGH technique, showed that a significant number of the above-mentioned samples (the majority proceeding from the young adult) displayedloss of genetic material in a concrete region of the chromosome16p. Later results showed that a gene located in chromosome 16p (patent pending) is deleted in colon cancer, mostly in young people. The study has been performed by q-PCR from DNA obtained fromparaffin-embedded samples in 93 young patients (diagnosed before the age of 45 years) and samples of 13 patients diagnosed of colon cancer with ages above 70. To complete this study, we ask for tumor DNA from 50 patients diagnosed of colon cancer aged between 46 to 69 years old and 50 patients diagnosed of colon cancer over 70.