Modificadores genéticos de susceptibilidad y gravedad del asma: análisis de los genes más robustamente asociados e influencia del trasfondo gémico ancestral.

Asthma is a complex phenotype with a considerably high prevalence in the Spanish population (>6%). Familiar clustering and twin studies indicate an important genetic influence for this disease. Under the hypothesis that different common genetic risk factors, common in the population, might explain asthma predisposition, our project aims to evaluate whether common variants of candidate genes, previously involved in the disease, constitute risk factors for asthma susceptibility/severity in the Spanish population. In samples from US, we have previously identified asthma risk variants in MYLK, CTTN, S1PR1 (Genet Epidemiol 2007, 2008 y J Allergy Immunol 2010), an S1PR3 genes (publication pending). These results have not been replicated in independent samples. Thus, in order to replicate previous findings, we aim to study the association of common variants of these 4 genes in the Spanish population using asthma cases an controls from the general population.